Characterization Services
In addition to standardized tests, Advanced BioDesign customizes procedures to be able to live up to your goals. You can include the following technology to characterize your antibody:
- Purity assessment
- ELISA test analysis (using one or different antigens)
- Western Blot analysis
- FACS analysis
- Sequence Confirmation
- Epitope Mapping
- Size Exclusion Chromatography (SEC) analysis
- Isoelectric Focusing (IEF) analysis
- Surface Plasmon Resonance (SPR) analysis
- Non exhaustive list…
Antibody Engineering
Advanced BioDesign is able to conduct projects involving recombinant antibody gene manipulation. These include V-region discovery and sequencing, isotype switching, in vitro affinity maturation as a part of a full package involving «humanization», production of stable cell line development and delivery of quantities of purified antibody following GMP requirements.
Key areas of competence:
- V-region discovery and sequencing
- Cloning plasmid and/or expression vector assembly
- In vitro affinity maturation
- Chimeric antibodies
- Isotype switching (from IgM or IgE in IgG)
- Humanization (CDR grafting)
- Cell line development (GMP or non GMP compliancy)
Cell banking
A cell bank is an essential element in the production of uniform biological products. Advanced BioDesign’s cell banking system provides the assurance that a sufficient supply of material will be available for the life of product.
