R&D

SEFALDIN ®

SEFALDIN ® , an innovative way for cancer treatment.

Nowadays, there are three principals’ ways to treat cancer: surgery, radiotherapy and chemotherapy. For some types of cancer, it is possible to make some hormonal therapy, immunotherapy or personalized therapy (cellular therapy, stem cells, …). Depend of the stage of the cancer, these treatments can be used alone, successively or in association.

Chemotherapeutic drugs used to treat cancer now, are cytotoxic agent that block the division of the cells and therefore stop or slow down the growth of cancer. But these agents do not make any difference between “good” cells and “cancerous” cells. Chemotherapy brings about the death of cancerous cells as well as healthy cells that divide quickly, such as those that line the mouth and intestines or cause your hair to grow.

Damage to healthy cells may cause side effect which decrease the life quality of the treated patient and limiting the effective doses and the treatment time.

Advanced Biodesign has developed a novel therapeutic approach against cancer. It consists to blocks specifically the intracellular mechanism of detoxification that cancerous cells develop in order to escape form the programmed cell death called apoptosis.

This innovative therapeutic approach, represent an alternative to actual treatment for to two major characteristics:

  • The ability to eradicate tumor even those containing Cancer Initiating Cells (CIC), which are cells responsible for the relapse and for most of them are chemoresistant.
  • The potential to limit the secondary effect due to a better accuracy by targeting specifically the cancerous cells with a compound that is reversibly cytostatic effect on normal cells.

Acute Myeloid Leukemia (AML) is the first cancer model in order to prove our concept. Many other in vitro studies were completed successfully on a large cancer panel, even challenging cancer cell just like Triple Negative Breast Cancer or EGFR mutant cell line.