APOCELL, a novel biomarker for monitoring apoptosis.

Apoptosis is a tightly regulated process of programmed cell death that occurs in multicellular organisms. Apoptosis is a fundamental mechanism inherent in cells for the elimination of senescent and damaged cells as well as for the proper functioning of the immune system. Contrary to necrosis in which cell swelling takes place, apoptosis is characterized by cell shrinkage, condensation of chromatin, fragmentation of DNA into multiples of 120 base pairs and cross-linking of cytoplasmic constituents into apoptotic bodies that are detergent insoluble.

Apoptosis is involved in a variety of normal and pathological biological events and can be, even, induced by wide variety of signals, number of chemicals (chemotherapeutic agents), irradiation, and infection by viruses or by gram-negative bacteria. Detecting and quantifying specific biomarkers can have therapeutic efficacy in numerous clinical indications, especially in cancer, in neurodegenerative, in immunodeficient, in infectious diseases and trauma.

Advanced BioDesign has developed an ex vivo method for the tracking of apoptosis which is based on the detection of apoptosis biomarkers in a biological sample of a subject with a specific monoclonal antibody.