Science

ALDH FAMILY

Aldehyde Dehydrogenases (ALDHs) belong to a family of enzymes that play a key role in the metabolism of endogenous and exogenous aldehydes. This group of intracellular enzymes plays a pivotal role in embryogenesis and cell differentiation as well as in cancer progression by mediating retinoic acid signalling. Their functional activity also extends to cellular redox homeostasis via detoxification of reactive aldehydes derived from lipid peroxidation and other metabolic processes thus, playing a major cytoprotective role in cells.

 

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MECHANISM OF ACTION

ABD-3001 A FIRST-IN-CLASS INHIBITOR

ABD-3001 is a suicidal inhibitor of ALDH1 and 3. It blocks the enzyme activity irreversibly causing rapid accumulation of reactive aldehydes in tumour cells, beyond critical threshold. The accumulated aldehydes, notably HNE and MDA form genotoxic adducts with protein and DNA affecting the oncogenic signalling pathways that participate in cell proliferation.

 

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Our vision

Advanced Biodesign

Based on our expertise in cancer metabolism and know-how in specific cell death called “apoptosis”, we will develop a new way to treat cancer to overcome actual stratification of cancer to bring new hope for patient.  By focusing on rare or bad-prognostic cancer, Advanced BioDesign offer innovative therapy to target markets with high unmet medical needs in cancer.  

News

Advanced BioDesign against TNBC

THERALDIN®TNBC, a multidisciplinary research program coordinated by Advanced Biodesign,  aims to elucidate the role of ALDH in triple-negative breast cancer (TNBC). In this context, a DIMATE-based therapy that is currently under investigation holds promise in the treatment of this aggressive disease.

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Advanced BioDesign welcomes Prof. Pierre Tambourin to its scientific advisory board

A world-renowned expert in molecular oncology research, Prof. Tambourin will assist Advanced BioDesign’s teams in developing DIMATE, which has the potential to become a major new targeted therapy in the treatment of resistant cancers.

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