Science

ALDH FAMILY

Aldehyde Dehydrogenases (ALDHs) belong to a family of enzymes that play a key role in the metabolism of endogenous and exogenous aldehydes. This group of intracellular enzymes plays a pivotal role in embryogenesis and cell differentiation as well as in cancer progression by mediating retinoic acid signalling. Their functional activity also extends to cellular redox homeostasis via detoxification of reactive aldehydes derived from lipid peroxidation and other metabolic processes thus, playing a major cytoprotective role in cells.

 

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MECHANISM OF ACTION

ABD-3001 A FIRST-IN-CLASS INHIBITOR

ABD-3001 is a suicidal inhibitor of ALDH1 and 3. It blocks the enzyme activity irreversibly causing rapid accumulation of reactive aldehydes in tumour cells, beyond critical threshold. The accumulated aldehydes, notably HNE and MDA form genotoxic adducts with protein and DNA affecting the oncogenic signalling pathways that participate in cell proliferation.

 

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Our vision

Advanced Biodesign

Based on our expertise in cancer metabolism and know-how in specific cell death called “apoptosis”, we will develop a new way to treat cancer to overcome actual stratification of cancer to bring new hope for patient.  By focusing on rare or bad-prognostic cancer, Advanced BioDesign offer innovative therapy to target markets with high unmet medical needs in cancer.  

News

Advanced BioDesign joins ENHPATHY consortium to increase its knowledge in genetic alterations in hematologic cancers

Lyon, France, January 21, 2019 - Consortium gathers 27 organizations from 11 countries to work on enhanceropathies; will receive €4M from European Commission over next four years Lyon, France, January 21, 2020 – Advanced BioDesign, a French pre-clinical stage biotechnology company focused on the development of a new treatment against resistant cancers, today announces it has teamed up with 27 European academic and industrial organizations from 11 countries to form the multidisciplinary science consortium, ENHPATHY.

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Advanced BioDesign Present Preclinical Result at 61st ASH Annual Meeting

Advanced BioDesign has presented a poster at the 61st American Society of Hematology (ASH) Annual Meeting with their rational on its lead compound ABD-3001, as a treatment of patients with refractory or relapse Acute Myeloid Leukemia (r/r AML).

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